Is your music on an external drive?
There seems to be a problem with indexing a particular drive. This is noted by
- spotlightknowledged - High CPU Use - Responsible for indexing files on your drives
- media-indexer - High CPU Use - Specifically for indexing media files like Music.
- suggestd - High CPU Use - Processes the info gained from the indexed files
I would start by eliminating the Hub and all external devices to see if it resolves the problems, then start adding drives directly connected to the Mac. This is one source of a Kernel Panic problems and why it says it may be Hardware related. See if it makes a difference when you add the Hub to the mix. Many times the Hub has been identified as the source of the problem. I assume your Hub is self powered, as there may not be enough power provided by USB. If you are able to identify an external device causing the problem, then steps may be taken to resolve it.
I would also experiment with Rebuilding the Spotlight Index and excluding some of the drives to see if there is a particular drive that is not allowing Spotlight to successfully index the files. It will take some time to let Spotlight finish the index.
Rebuild the Spotlight index on your Mac - Apple Support
As for software, you look pretty good. The one thing that stands out related to the indexing of the files is the Adobe Content Synchronizer Finder Extension. Not sure if you are actively using Adobe Acrobat or if it was installed for another reason. The one kernel panic started on 9/18 when Adobe Acrobat was installed for the second time. I have no specific information about a compatibility problem with Sequoia so I can't call out that specific app, but if you want to test with Adobe installed start by using the uninstaller, then make sure these files/folder have also been removed:
- Applications/Utilities/Adobe Sync
- /Library/LaunchDaemons/com.adobe.ARMDC.Communicator.plist
- /Library/LaunchDaemons/com.adobe.ARMDC.SMJobBlessHelper.plist
- /Library/LaunchDaemons/com.adobe.acc.installer.v2.plist
- /Library/LaunchAgents/com.adobe.ARMDCHelper.cc24aef4a1b90ed56a725c38014c95072f92651fb65e1bf9c8e43c37a23d420d.plist
- /Library/LaunchAgents/com.adobe.AdobeCreativeCloud.plist
- /Library/LaunchAgents/com.adobe.ccxprocess.plist
All those files are running on startup to support Adobe. You can find these files by going to Finder > Go > Go to Folder, then enter the first part of the location like /Library/LaunchDaemons or /Library/LaunchAgents, and you will see those files there.