Is it safe to delete Safari WebsiteData files in order to unbreak Time Machine backups?

Is it safe to delete files in "~/Library/Containers/com.apple.Safari/Data/Library/WebKit/WebsiteData/Default/" ? My Time Machine backups are failing with the error message that a particular file "could not be backed up". The file it names is in the folder referenced above, its name is about 50 seemingly random alphanumeric characters, and it is buried in about 5 layers of folders with similarly long and random names." To unblock backups, I was thinking of just deleting the whole mess. Will this cause problems?

Thanks!