I see two oddities in your Etrecheck Report:
- Your external target drive for your failing backups:
disk4 - VendorCo SSD 3.0 2.10 TB
External USB Up to 480 Mb/s USB
disk4s1 - EFI (MS-DOS FAT32) [EFI] 210 MB
disk4s2 [APFS Container] 2.10 TB
disk5 [APFS Virtual drive] 2.10 TB
disk5s2 - SSD (APFS) (626.98 GB used)
Note the speed shown is 480 Mb/s, which is maybe ~ one tenth the speed of a decent SSD. You may be using a charging USB-C cable instead of a high speed rated USB-C data cable, which should get 5 Gb/s to 40 Gb/s (5000 Mb/s to 40000 Mb/s). So it might be you are using a USB-C cable not suited to SSD backups, too slow, as I had suggested in my earlier post.
- Another possibility is a low quality external SSD. Yours is identified as a "VendorCO SSD" with an odd size 2.1 TB. See this post, often counterfeit SSDs self identify as "VendorCO," which is a generic placeholder the true vendor's name. Where did you get this SSD from?
https://www.hdsentinel.com/how_to_detect_fake_pendrive_memory_card.php
https://www.facebook.com/groups/1397842270480207/posts/3815493112048432/
There are many online posts about "VendorCO" external drives that are fake SSDs or show very slow performance and incorrect disk storage.
Yours claims to be using 600 GB already -- but isn't this for your target backup drive, it should be dedicated to the backups, what is in that 600 GB of used storage. This seems anomalous also.
I would obtain a reliable known vendor SSD model and try it for your backups. Well known brands include OWC, Samsung, Western Digital, Seagate, LaCie, Crucial, Kingston ... there are many. Sold on sites like Amazon, Best Buy, BH Photo, etc.