The error code -50 you're seeing generally implies some kind of file or system corruption which is preventing the operation.
First off, let's try a couple of troubleshooting steps to isolate and hopefully resolve the issue. Start by rebooting your Mac - this can often help with system glitches. If the issue persists, try connecting the drive to a different USB port or using a different cable to rule out any hardware issues.
Next, let's check the drive for errors. Go to Applications > Utilities > Disk Utility. Select the external drive from the sidebar and click on "First Aid." This should check the disk for any errors and fix them if possible.
If you're still having trouble, it might be due to some specific permissions or settings on the drive. You can try reformatting the drive (after backing up any important data, of course). Remember, when you reformat, choose "Mac OS Extended (Journaled)" for the format, and "GUID Partition Map" for the scheme.
If none of the above steps help, you may want to consider looking at the Apple support articles on disk permissions and troubleshooting external devices:
- Repair a storage device in Disk Utility on Mac
- If a storage device isn't working properly
To contact Apple Support directly, select the "Support" link on the lower left-hand side of this forum's web page.